Endocrine Abstracts

Introduction: The metabolic syndrome (MS) is a frequent complication of the obstructive sleep apnea hypopnea syndrome (OSAHS). Its predictive factors have to be known by the doctors setting in charge patients with OSAHS. The aim of this study was to determine the prevalence of the MS and its predictive factors in Tunisian patients with OSAHS.Methods: A retrospective study including 181 patients with OSAHS from the respiratory D department at the Abderrah...

Introduction: TSH-secreting pituitary adenomas are rare pituitary functioning tumors accounting for <2% of the pituitary adenomas. Their association to meningiomas is a very rare condition.We report a case of 55-year-old woman who had multinodular goiter with mild symptoms of hyperthyroidism. Blood tests showed inappropriate secretion of TSH and magnetic resonance imaging (MRI) revealed a pituitary tumor with maximum diameter of 13 mm that was extirp...

Introduction: Turner’s syndrome (TS) affects 1/2500 female births and it is characterized by growth retardation, dysmorphic syndrome and gonadal dysgenesis. Our objective was to describe the clinical, therapeutic and evolutive features of Tunisian patients with TS.Patients and Methods: It was a retrospective study including 23 patients with TS diagnosed between 1993 and 2019.We noted clinical, therapeutic and evolutive data for each patient.<p ...

Cushing disease (CD) is a rare affection due to an ACTH secreting pituitary adenoma with a hypercorticism as main consequence.The aim of this study was to assess glucose tolerance anomalies in CD.Patients: Twenty-one patients with a diagnosed CD were included; The majority of them (77.3%; n=17) were female. Mean age was 34.2 (19–54 years) and mean BMI 31.9 kg/m2 (25.9–43.7). Mean progression period of ...

Background: Although the most common causes of hypokalemia are diuretic use and gastrointestinal losses, elevated cortisol levels can also cause hypokalemia through its effects on the renin-angiotensin-aldosterone system.Case report: A 56-year-old woman with a history of diabetes mellitus and hypertension, presented to our emergency department with fast progressing generalized weakness, abdominal discomfort and diarrhea. Digestive tract diseases were rul...

Low-grade gliomas are the most common brain tumor in children, accounting for 30–50% of central nervous system tumors in the pediatric age group. They can occur anywhere within the central nervous system (CNS) including the optic pathway (5%). When optic gliomas involve the hypothalamus, patients will often present endocrinopathy. Signs of such involvement can include growth failure and precocious puberty. In this report, we present the case of 8 years three months girls ...

Hypohidrotic ectodermal dysplasia (HED) is a rare genetic disorder characterized by the faulty development of the ectodermal structure, resulting in most notably anhydrosis/hypohydrosis, hypotrichosis and hypodontia. Affected individuals tend to have sparse scalp and body hair (Hypohidrotic), absent teeth (hypodontia) or small and pointed teeth. HED is associated with distinctive facial features including a proeminent forehead, thick lips, and flattened bridge of the nose. The...

Introduction: The 17 α-hydroxylase deficiency is a rare form of congenital adrenal hyperplasia. It is characterized by amenorrhea, impuberism, hypertension and hypokalemia. We report a case of 17α-hydroxylase deficiency in a patient with a 46,XX karyotype, which contrasted with the absence of Mullerian duct.Case report: An18-year-old female was referred for primary amenorrhea. Her parents were cousins. Her sister, who had the same features, die...

Background: The vitamin D is a pleiotropic hormone that plays a significant role on global health. However, vitamin D status in acromegaly has been poorly studied.The aim: The aim of this study was to assess the vitamin D status in acromegaly and compare it to a control group. Then to analyse bone remodeling and density markers based on the vitamin D levels.Methods: We conducted an evaluative cross sectional study in the Department...

Introduction: As Ramadan fasting is one of the five pillars of Islam, more than one billion muslims fast simultaneously worldwide. Patients with diabetes especially those with type 1 diabetes who fast during Ramadan, are at increased risk of diabetic ketoacidosis, particularly if their diabetes is poorly controlled before Ramadan. The aim of our study was to compare the incidences of diabetic Ketosis or ketoacidosis during in the month of Ramadan, the preceding month (Shaaban)...